MAP3K2 and NGLY1

Data Source:
BioGRID (two hybrid)

		MAP3K2	NGLY1
Description		mitogen-activated protein kinase kinase kinase 2	N-glycanase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs		Bosutinib Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)
Interacting Genes		24 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	18 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		10746	55768
HPRD ID		10068	10118
Ensembl ID		ENSG00000169967	ENSG00000151092
Uniprot IDs		A0A024RAH0 Q9Y2U5	Q96IV0
PDB IDs		2CU1 2NPT 5EX0 5HQ8	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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