MAP3K2 and SH2D2A

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAP3K2	SH2D2A
Description		mitogen-activated protein kinase kinase kinase 2	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Protein Binding SH3 Domain Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Angiogenesis Signal Transduction Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways			VEGFA-VEGFR2 Pathway
Drugs		Bosutinib Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)	Autoimmune thyroid disease ( 32581359) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		24 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1
Entrez ID		10746	9047
HPRD ID		10068	05152
Ensembl ID		ENSG00000169967	ENSG00000027869
Uniprot IDs		A0A024RAH0 Q9Y2U5	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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