DCTN6 and PMEPA1

Data Source:
BioGRID (pull down)

		DCTN6	PMEPA1
Description		dynactin subunit 6	prostate transmembrane protein, androgen induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Centrosome Cytosol Dynactin Complex	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Dynein Complex Binding	Protein Binding WW Domain Binding R-SMAD Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Breast size ( 27182965)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		7 interacting genes: APP CDK1 ERRFI1 HSPB2 NCOA3 PMEPA1 RPSA	11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		10671	56937
HPRD ID		09907	09415
Ensembl ID		ENSG00000104671	ENSG00000124225
Uniprot IDs		O00399	Q5JY37 Q969W9
PDB IDs		3TV0
Enriched GO Terms of Interacting Partners?
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