DCTN6 and NCOA3

Data Source:
BioGRID (two hybrid)

		DCTN6	NCOA3
Description		dynactin subunit 6	nuclear receptor coactivator 3
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Centrosome Cytosol Dynactin Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Dynein Complex Binding	RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Disordered Domain Specific Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Histone Acetylation Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Breast size ( 27182965)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		7 interacting genes: APP CDK1 ERRFI1 HSPB2 NCOA3 PMEPA1 RPSA	82 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		10671	8202
HPRD ID		09907	03570
Ensembl ID		ENSG00000104671	ENSG00000124151
Uniprot IDs		O00399	Q59EE8 Q9Y6Q9
PDB IDs		3TV0	1KBH 3L3X 3L3Z 6ES7 6SQC
Enriched GO Terms of Interacting Partners?
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