KHDRBS1 and ARHGEF4

Data Source:
BioGRID (unspecified method)

		KHDRBS1	ARHGEF4
Description		KH RNA binding domain containing, signal transduction associated 1	Rho guanine nucleotide exchange factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex	Cytosol Ruffle Membrane
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Spermatogenesis Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Filopodium Assembly Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Degraded stimulus continuous performance test score ( 31596458) Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) ( 26222057)
Interacting Genes		110 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	7 interacting genes: APC CDC42 HLA-B HSF2BP KHDRBS1 RAC1 RHOA
Entrez ID		10657	50649
HPRD ID		03926	05559
Ensembl ID		ENSG00000121774	ENSG00000136002
Uniprot IDs		Q07666	Q9NR80 Q9NTG0
PDB IDs		2XA6 3QHE	2DX1 2PZ1 3NMX 3NMZ
Enriched GO Terms of Interacting Partners?
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