ARHGEF4

Description		Rho guanine nucleotide exchange factor 4
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GO Annotations	Cellular Component	Cytosol Ruffle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Filopodium Assembly Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Degraded stimulus continuous performance test score ( 31596458) Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) ( 26222057)
Novel Interacting Genes		1 novel interacting genes: CTNNB1
Interacting Genes		7 interacting genes: APC CDC42 HLA-B HSF2BP KHDRBS1 RAC1 RHOA
Entrez ID		50649
HPRD ID		05559
Ensembl ID		ENSG00000136002
Uniprot IDs		Q9NR80 Q9NTG0
PDB IDs		2DX1 2PZ1 3NMX 3NMZ
Enriched GO Terms of Interacting Partners?
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