DTX3L and DTX1

Data Source:
HPRD (in vitro, in vivo)

		DTX3L	DTX1
Description		deltex E3 ubiquitin ligase 3L	deltex E3 ubiquitin ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Early Endosome Cytosol Early Endosome Membrane Protein-containing Complex	Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Endosome To Lysosome Transport Histone Monoubiquitination Protein Transport Viral Process Protein Ubiquitination Positive Regulation Of Protein Binding Histone H2A Ubiquitination Histone H2B Ubiquitination Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Transcription, DNA-templated Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)	Body mass index ( 26426971) Coffee consumption ( 29367735) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		20 interacting genes: DTX1 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W	21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U
Entrez ID		151636	1840
HPRD ID		16843	03991
Ensembl ID		ENSG00000163840	ENSG00000135144
Uniprot IDs		Q8TDB6	Q86Y01
PDB IDs		3PG6	6Y5N 6Y5P
Enriched GO Terms of Interacting Partners?
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