ARHGAP45 and TRIM50

		ARHGAP45	TRIM50
Description		Rho GTPase activating protein 45	tripartite motif containing 50
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen	Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Signal Transduction Neutrophil Degranulation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Protein Ubiquitination
Pathways		Rho GTPase cycle Neutrophil degranulation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		9 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 TRIM50 ZUP1	40 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SNAI1 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620
Entrez ID		23526	135892
HPRD ID		03097	15566
Ensembl ID		ENSG00000180448	ENSG00000146755
Uniprot IDs		B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619	B7ZLG2 Q2M204 Q86XT4
PDB IDs		3D25 3FT3
Enriched GO Terms of Interacting Partners?
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