ARHGAP45 and GMIP

Data Source:
BioGRID (two hybrid)

		ARHGAP45	GMIP
Description		Rho GTPase activating protein 45	GEM interacting protein
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GO Annotations	Cellular Component	Extracellular Region Cytosol Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen	Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Intracellular Signal Transduction Neutrophil Degranulation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Negative Regulation Of GTPase Activity Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Rho GTPase cycle Neutrophil degranulation	Rho GTPase cycle
Drugs
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Refractive error ( 32231278) Schizophrenia ( 23974872) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		9 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 TRIM50 ZUP1	5 interacting genes: ARHGAP45 CDC42 GEM RAC1 RHOA
Entrez ID		23526	51291
HPRD ID		03097	11005
Ensembl ID		ENSG00000180448	ENSG00000089639
Uniprot IDs		B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619	A0A024R7N1 B4DLZ1 Q9P107
PDB IDs		3D25 3FT3	3QWE
Enriched GO Terms of Interacting Partners?
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