IFITM3 and MS4A3

Data Source:
BioGRID (two hybrid)

		IFITM3	MS4A3
Description		interferon induced transmembrane protein 3	membrane spanning 4-domains A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Immune Response Response To Virus Negative Regulation Of Viral Transcription Response To Interferon-gamma Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway	Neutrophil Degranulation Regulation Of Cell Cycle
Pathways		Interferon alpha/beta signaling	Neutrophil degranulation
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252)	Alzheimer's disease ( 24755620) Vitamin B12 levels ( 22367966)
Interacting Genes		27 interacting genes: ABHD16A AQP6 CD53 ELOVL2 ERGIC3 FAM210B FFAR2 FKBP7 GLP1R GPR37 GPRC5D KIR2DL3 LYPD5 MS4A3 NEDD4 OPRM1 PLP1 PTAFR REEP4 RETREG3 SGPL1 SLC10A1 SLC10A2 SLC16A7 TMEM14B TMEM86B VKORC1	38 interacting genes: ADIPOQ ATP6V0B BMP10 BNIP3 C4orf3 CCDC167 CD53 CD72 CDKN3 CLDN1 CLDN6 EFNA5 EMP3 ERG28 IFITM3 IGFBP5 MS4A13 NKG7 PLP1 PLPP6 SEC22A SGTA SLC22A14 SLC5A4 SMCO4 SMIM3 STX8 TEX264 TM4SF18 TMBIM6 TMEM107 TMEM140 TMEM182 TMEM218 TMEM239 VKORC1L1 YIPF6 ZFPL1
Entrez ID		10410	932
HPRD ID		05719	09403
Ensembl ID		ENSG00000142089	ENSG00000149516
Uniprot IDs		Q01628	Q96HJ5
PDB IDs
Enriched GO Terms of Interacting Partners?
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