KLHL12 and TTBK2

Data Source:
BioGRID (two hybrid, two hybrid)

		KLHL12	TTBK2
Description		kelch like family member 12	tau tubulin kinase 2
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GO Annotations	Cellular Component	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Extracellular Space Nucleus Cytoplasm Centriole Cytosol Ciliary Transition Zone Ciliary Basal Body
	Molecular Function	Protein Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Tau Protein Binding Tau-protein Kinase Activity Microtubule Plus-end Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Cerebellum Development Cerebellar Granular Layer Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Protein Localization To Microtubule Negative Regulation Of Microtubule Binding
Pathways		Degradation of DVL	Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Bipolar disorder ( 31043756) Hematocrit ( 32888494) MGMT methylation in smokers ( 26183928)
Interacting Genes		62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4	1 interacting genes: KLHL12
Entrez ID		59349	146057
HPRD ID		13925	10288
Ensembl ID		ENSG00000117153	ENSG00000128881
Uniprot IDs		Q53G59 Q9H7R2	Q6IQ55 Q8IWY7
PDB IDs		2VPJ 6TTK 6V7O	6U0K 6VRF
Enriched GO Terms of Interacting Partners?
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