MED21 and CDK8

Data Source:
HPRD (in vivo)

		MED21	CDK8
Description		mediator complex subunit 21	cyclin dependent kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Mediator Complex	Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs			Alvocidib
Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)	Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)
Interacting Genes		30 interacting genes: BLOC1S6 BORCS6 BRCA1 BTF3 CDK8 CDK9 ELOA ESR1 ESR2 HGS HNF4A HTT MAGEA6 MAGEB4 MED29 MIEF1 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 TRIM72 VAV2 ZNF655 ZSCAN1	38 interacting genes: AURKA BCL6 BMPR1A BUB1 CCNC CCND1 CCNH CDH1 CDKN2B CTDP1 ERBB2 ERCC3 ESR1 ESR2 H3C14 KRAS MAML1 MBP MCC MED12 MED21 MED25 MED26 MED8 MED9 MLH3 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77
Entrez ID		9412	1024
HPRD ID		09156	04422
Ensembl ID		ENSG00000152944	ENSG00000132964
Uniprot IDs		A0A024RAW0 Q13503	P49336
PDB IDs			3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41
Enriched GO Terms of Interacting Partners?
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