EIF1 and UPF2

Data Source:
HPRD (in vitro, two hybrid)

		EIF1	UPF2
Description		eukaryotic translation initiation factor 1	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic 43S Preinitiation Complex	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Diverticular disease ( 30177863)
Interacting Genes		8 interacting genes: APP EIF4G1 HMGB1 HMGB2 MAPK6 OLFM2 RASA1 UPF2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		10209	26019
HPRD ID		15449	10405
Ensembl ID		ENSG00000173812	ENSG00000151461
Uniprot IDs		P41567 Q6IAV3	Q9HAU5
PDB IDs		2IF1 4KZX 4KZY 6YBW 6ZMW 6ZP4 6ZVJ 7A09	1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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