G3BP1 and RASA1

Data Source:
HPRD (in vitro, in vivo)

		G3BP1	RASA1
Description		G3BP stress granule assembly factor 1	RAS p21 protein activator 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding DNA/RNA Helicase Activity	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Ras Protein Signal Transduction Viral Process DNA Duplex Unwinding Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Nucleic Acid Phosphodiester Bond Hydrolysis	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways			Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		12 interacting genes: APP CSK DTX1 EPHA8 FBXO25 IL7R LCK LINC01554 PIN1 PPIA RASA1 USP10	94 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NRAS NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		10146	5921
HPRD ID		06569	00745
Ensembl ID		ENSG00000145907	ENSG00000145715
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	P20936 Q59GK3
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY
Enriched GO Terms of Interacting Partners?
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