G3BP1 and EPHA8

Data Source:
BioGRID (two hybrid)

		G3BP1	EPHA8
Description		G3BP stress granule assembly factor 1	EPH receptor A8
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding DNA/RNA Helicase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	Ras Protein Signal Transduction Viral Process DNA Duplex Unwinding Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Nucleic Acid Phosphodiester Bond Hydrolysis	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		12 interacting genes: APP CSK DTX1 EPHA8 FBXO25 IL7R LCK LINC01554 PIN1 PPIA RASA1 USP10	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		10146	2046
HPRD ID		06569	01493
Ensembl ID		ENSG00000145907	ENSG00000070886
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	P29322
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5	1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?
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