G3BP1 and DTX1

Data Source:
BioGRID (two hybrid)

		G3BP1	DTX1
Description		G3BP stress granule assembly factor 1	deltex E3 ubiquitin ligase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding DNA/RNA Helicase Activity	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ras Protein Signal Transduction Viral Process DNA Duplex Unwinding Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Nucleic Acid Phosphodiester Bond Hydrolysis	Transcription, DNA-templated Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor
Pathways			Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)	Body mass index ( 26426971) Coffee consumption ( 29367735) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		12 interacting genes: APP CSK DTX1 EPHA8 FBXO25 IL7R LCK LINC01554 PIN1 PPIA RASA1 USP10	21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U
Entrez ID		10146	1840
HPRD ID		06569	03991
Ensembl ID		ENSG00000145907	ENSG00000135144
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	Q86Y01
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5	6Y5N 6Y5P
Enriched GO Terms of Interacting Partners?
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