NAMPT and USP49

Data Source:
BioGRID (two hybrid)

		NAMPT	USP49
Description		nicotinamide phosphoribosyltransferase	ubiquitin specific peptidase 49
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Nuclear Speck Cell Junction Extracellular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Histone Binding
	Biological Process	Signal Transduction Cell-cell Signaling Circadian Rhythm Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinamide salvaging	Ub-specific processing proteases
Drugs		GMX1777 Daporinad
Diseases
GWAS		Grapefruit juice consumption ( 31046077)	Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		5 interacting genes: ADORA2A AKT2 FANCA GGT1 USP49	12 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774
Entrez ID		10135	25862
HPRD ID		09938	10075
Ensembl ID		ENSG00000105835	ENSG00000164663
Uniprot IDs		A0A024R718 P43490	Q70CQ1
PDB IDs		2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB
Enriched GO Terms of Interacting Partners?
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