RAD50 and RECQL5

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RAD50	RECQL5
Description		RAD50 double strand break repair protein	RecQ like helicase 5
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleoplasm Membrane Mre11 Complex Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol RNA Polymerase II, Holoenzyme
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded Telomeric DNA Binding Protein Binding ATP Binding 3'-5' Exonuclease Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-quadruplex DNA Binding	RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Viral Process Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Nucleoside Monophosphate Phosphorylation Chromosome Organization Involved In Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Capping	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Drug Cell Division Chromosome Separation Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 20159242 31959851 30929738 27611488 27182965 31619474 29273806) Asthma (childhood onset) ( 30929738 24241537 29273806) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23886662 25865352 25574825 26482879) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 18846228) Inflammatory skin disease ( 25574825) Itch intensity from mosquito bite ( 28199695) Neutrophil percentage of white cells ( 32888494 27863252) Polycystic ovary syndrome ( 30566500 26416764) Rosacea symptom severity ( 29771307) Sum eosinophil basophil counts ( 27863252) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		10 interacting genes: DCLRE1C EP300 MDC1 MRE11 NBN RECQL5 RINT1 SUMO2 TERF2IP TP53BP1	20 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		10111	9400
HPRD ID		04950	04806
Ensembl ID		ENSG00000113522	ENSG00000108469
Uniprot IDs		A5D6Y3 Q92878	A0A024R8M9 A0A024R8S8 B3KQK2 O94762 Q8WYH5
PDB IDs		5GOX	4BK0 5LB3 5LB5 5LB8 5LBA
Enriched GO Terms of Interacting Partners?
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