CDH10 and JUP

Data Source:
BioGRID (two hybrid)

		CDH10	JUP
Description		cadherin 10	junction plakoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Catenin Complex Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Specialization Membrane	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Calcium Ion Binding Cadherin Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Adherens junctions interactions	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Anorexia nervosa ( 31308545) Autism ( 19404256) General risk tolerance (MTAG) ( 30643258) Hepcidin/ferritin ratio ( 27846281) Idiopathic dilated cardiomyopathy ( 29495422) Obsessive-compulsive disorder ( 24821223) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Heel bone mineral density ( 30598549 28869591)
Interacting Genes		5 interacting genes: CDH6 CDH9 COPS6 JUP PTN	52 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 ZFYVE9
Entrez ID		1008	3728
HPRD ID		05187	01414
Ensembl ID		ENSG00000040731	ENSG00000173801
Uniprot IDs		Q9Y6N8 X5D8X5 X5DNG6	A0A0S2Z487 P14923
PDB IDs			3IFQ
Enriched GO Terms of Interacting Partners?
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