SAE1 and UBA2

Data Source:
HPRD (in vitro, in vivo)

		SAE1	UBA2
Description		SUMO1 activating enzyme subunit 1	ubiquitin like modifier activating enzyme 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity	Magnesium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Protein Ubiquitination Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion	Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		22 interacting genes: AGTR1 APP CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39	17 interacting genes: BRIX1 CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I
Entrez ID		10055	10054
HPRD ID		18010	11658
Ensembl ID		ENSG00000142230	ENSG00000126261
Uniprot IDs		A0A024R0R4 Q9UBE0	Q9UBT2
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ	1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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