UBA2 and ETV4

Data Source:
BioGRID (enzymatic study)

		UBA2	ETV4
Description		ubiquitin like modifier activating enzyme 2	ETS variant transcription factor 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	MAPK6/MAPK4 signaling
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS
Interacting Genes		17 interacting genes: BRIX1 CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I	14 interacting genes: APP ATXN1 EP300 EPAS1 HIF1A HOXD4 HTT JUN MEOX2 SAE1 SMAD4 SRF STK11 UBA2
Entrez ID		10054	2118
HPRD ID		11658	02833
Ensembl ID		ENSG00000126261	ENSG00000175832
Uniprot IDs		Q9UBT2	P43268
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ	4CO8 4UUV 5ILU
Enriched GO Terms of Interacting Partners?
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