FXYD6-FXYD2 and APH1B

Data Source:
BioGRID (two hybrid)

		FXYD6-FXYD2	APH1B
Description		FXYD6-FXYD2 readthrough	aph-1 homolog B, gamma-secretase subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Plasma Membrane Endosome Membrane Integral Component Of Membrane Transport Vesicle Gamma-secretase Complex
	Molecular Function		Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process		Notch Signaling Pathway Notch Receptor Processing Locomotory Behavior Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		33 interacting genes: APH1B APOL3 AQP6 AVPR2 BEST1 BNIP3 CERS4 CLDN5 FAM210B GPR152 GPR37L1 GPRC5D MTIF3 PGRMC2 RNF170 SLC10A1 SLC10A6 SLC16A13 SLC19A3 SLC2A13 SLC34A2 SLC35C2 SLC7A8 SPCS1 TLCD4 TMEM14B TMEM167B TMEM205 TMEM41A TMPPE TMX2 TRHR UNC93A	7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1
Entrez ID		100533181	83464
HPRD ID			06361
Ensembl ID		ENSG00000255245	ENSG00000138613
Uniprot IDs		A0A087WZ82 A0A0A6YYL5	Q8WW43
PDB IDs
Enriched GO Terms of Interacting Partners?
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