APH1B and VSTM1

Data Source:
BioGRID (two hybrid)

		APH1B	VSTM1
Description		aph-1 homolog B, gamma-secretase subunit	V-set and transmembrane domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Endosome Membrane Integral Component Of Membrane Transport Vesicle Gamma-secretase Complex	Extracellular Space Integral Component Of Membrane
	Molecular Function	Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Cytokine Activity
	Biological Process	Notch Signaling Pathway Notch Receptor Processing Locomotory Behavior Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Immune System Process Signal Transduction
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Small cell lung carcinoma ( 28604730)
Interacting Genes		7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1	28 interacting genes: ADGRG3 APH1B AQP6 ARL13B CD53 CLDN7 CLDN9 CLEC10A COQ9 ERGIC3 FATE1 FBXO2 FCGR1A FNDC9 GJB5 GOLM1 GPX8 HCST KCNJ6 LAMP1 LMNA LRRC4C MANSC1 MFSD4B MRM1 PLPP2 STMN4 TMEM248
Entrez ID		83464	284415
HPRD ID		06361	15615
Ensembl ID		ENSG00000138613	ENSG00000189068
Uniprot IDs		Q8WW43	D2DJS5 D2DJS6 Q6UX27
PDB IDs
Enriched GO Terms of Interacting Partners?
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