APH1B and TM4SF4

Data Source:
BioGRID (two hybrid)

		APH1B	TM4SF4
Description		aph-1 homolog B, gamma-secretase subunit	transmembrane 4 L six family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Endosome Membrane Integral Component Of Membrane Transport Vesicle Gamma-secretase Complex	Integral Component Of Membrane
	Molecular Function	Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Protein Binding
	Biological Process	Notch Signaling Pathway Notch Receptor Processing Locomotory Behavior Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Tissue Regeneration
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Alanine transaminase levels ( 29403010) Gallstone disease ( 30504769 27094239) Gamma glutamyl transferase levels ( 29403010) Ischemic stroke (large artery atherosclerosis) ( 29531354) Serum uric acid levels ( 30993211) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1	22 interacting genes: APH1B CD79A CLEC17A CMTM2 CREB3 ERGIC3 FATE1 FFAR2 GJB1 GJB4 GJB5 GLP1R GPR101 GPR37L1 GPR42 GPX8 KCNK5 LHFPL5 OPRM1 SLC10A6 TBXA2R TMEM14B
Entrez ID		83464	7104
HPRD ID		06361	07585
Ensembl ID		ENSG00000138613	ENSG00000169903
Uniprot IDs		Q8WW43	P48230
PDB IDs
Enriched GO Terms of Interacting Partners?
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