KRT18 and RHPN2

Data Source:
HPRD (in vitro, two hybrid)

		KRT18	RHPN2
Description		keratin 18	rhophilin Rho GTPase binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Intermediate Filament Adherens Junction External Side Of Plasma Membrane Protein-containing Complex Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cell Cycle Anatomical Structure Morphogenesis Response To Fructose Viral Process Keratinization Response To Nutrient Levels Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Cornification Hepatocyte Differentiation Mesenchymal Stem Cell Differentiation Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion Cholangiocyte Apoptotic Process	Signal Transduction
Pathways		Keratinization Formation of the cornified envelope	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Cleft lip with or without cleft palate ( 28054174) Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)	Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 30529582 19011631 24836286 24737748 31826910) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Optic disc size ( 31809533)
Interacting Genes		91 interacting genes: BBS1 BBS2 BBS4 BBS7 C1orf109 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT5 KRT6A KRT6C KRT71 KRT72 KRT79 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ	6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1
Entrez ID		3875	85415
HPRD ID		01020	10192
Ensembl ID		ENSG00000111057	ENSG00000131941
Uniprot IDs		A0A024RAY2 P05783	Q8IUC4
PDB IDs			2VSV
Enriched GO Terms of Interacting Partners?
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