SH2B3 and ZAP70

Data Source:
HPRD (in vitro)

		SH2B3	ZAP70
Description		SH2B adaptor protein 3	zeta chain of T cell receptor associated protein kinase 70
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Stem Cell Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Protein Tyrosine Kinase Binding	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Neutrophil Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Negative Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Intracellular Signal Transduction Monocyte Homeostasis Megakaryocyte Development Cellular Response To Interleukin-3 Thrombopoietin-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Erythrocyte Development Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Negative Regulation Of Kit Signaling Pathway Cellular Response To Chemokine	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Regulation of KIT signaling Negative regulation of FLT3 Factors involved in megakaryocyte development and platelet production	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules
Drugs		Pazopanib	Staurosporine Fostamatinib
Diseases		Type I diabetes mellitus	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Allergic rhinitis ( 30013184) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 29273807) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430479 19430483 27841878 21909115 28739976 27618447 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 19198610 32888494) Fibrinogen levels ( 28107422 26561523) Gastroesophageal reflux disease ( 31527586) Glaucoma (multi-trait analysis) ( 31959993) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) IgA levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 31959993) Ischemic stroke ( 24262325 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Left ventricular end-diastolic volume ( 32382064) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 28017375) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 26343387) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 22139419 24026423 32888494 25705162 20139978 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763 27992413) Reaction time ( 27046643) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 30423114 24390342 20453842) Sarcoidosis ( 26051272) Small vessel stroke (CCS or TOAST classification) ( 32047268) Small vessel stroke (CCSp classification) ( 32047268) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 27182965 28928442) Tumor necrosis factor levels ( 32805626) Type 1 diabetes ( 21829393 25751624 19430480 17554300 30572963) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 32499647) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: CD247 EGFR ERBB2 ERBB3 ERBB4 FLNA GRB2 KIT LCK MET TNS2 ZAP70	66 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		10019	7535
HPRD ID		05480	01495
Ensembl ID		ENSG00000111252	ENSG00000115085
Uniprot IDs		B7Z7K6 F5GYM4 Q59H48 Q96BA5 Q9UQQ2	P43403
PDB IDs			1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
Enriched GO Terms of Interacting Partners?
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