SBK3 and EXOSC2

Data Source:
BioGRID (two hybrid)

		SBK3	EXOSC2
Description		SH3 domain binding kinase family member 3	exosome component 2
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Protein Phosphorylation	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		13 interacting genes: AIMP2 ATXN7L2 C1orf105 CRY2 DMAP1 EXOSC2 GATAD2B MBD3L2 NOTO POLDIP3 SMAD3 SNRNP35 TNNT1	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		100130827	23404
HPRD ID			03758
Ensembl ID		ENSG00000231274	ENSG00000130713
Uniprot IDs		P0C264	B3KQW2 Q13868
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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