EXOSC2 and GALNT13

Data Source:
BioGRID (two hybrid)

		EXOSC2	GALNT13
Description		exosome component 2	polypeptide N-acetylgalactosaminyltransferase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	O-glycan Processing Protein Phosphopantetheinylation Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	O-linked glycosylation of mucins
Drugs
Diseases
GWAS			Aging traits ( 17903295) Blood trace element (Zn levels) ( 23720494) Body mass index ( 24348519) Coronary artery disease in type 1 diabetes ( 29695241) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Liver enzyme levels (alanine transaminase) ( 24124411) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Placental abruption ( 29884306) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Schizophrenia or schizoaffective disorder ( 31591465) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408	2 interacting genes: EXOSC2 SKIV2L
Entrez ID		23404	114805
HPRD ID		03758	16325
Ensembl ID		ENSG00000130713	ENSG00000144278
Uniprot IDs		B3KQW2 Q13868	B3KY85 Q8IUC8
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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