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EXOSC2 and EXOSC4
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
EXOSC2
EXOSC4
Description
exosome component 2
exosome component 4
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Intracellular Membrane-bounded Organelle
Molecular Function
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
7S RNA Binding
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Asthma (
31959851
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Interacting Genes
18 interacting genes:
DIS3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
GALNT13
KHSRP
MRPL48
MTREX
PALS2
PTEN
RNF8
SBK3
ST6GALNAC1
UPF1
ZNF408
33 interacting genes:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HBS1L
HNRNPD
LNX1
LRRC8D
MPZL1
MTREX
NEK1
PALS2
POLE2
PPARA
PTEN
SDCBP
SKIV2L
SMPD4
TSEN15
UPF1
UPF2
UPF3B
Entrez ID
23404
54512
HPRD ID
03758
16221
Ensembl ID
ENSG00000130713
ENSG00000178896
Uniprot IDs
B3KQW2
Q13868
Q9NPD3
PDB IDs
2NN6
6D6Q
6D6R
6H25
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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