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SRA1 and TFAP2A
Data Source:
BioGRID
(far western blotting)
SRA1
TFAP2A
Description
steroid receptor RNA activator 1
transcription factor AP-2 alpha
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
SCAR Complex
Cell Leading Edge
Intercellular Bridge
Ribonucleoprotein Complex
Chromatin
Nucleus
Nucleoplasm
Molecular Function
Steroid Receptor RNA Activator RNA Binding
DNA Binding
Transcription Coactivator Activity
Protein Binding
Nuclear Receptor Coactivator Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Regulation Of Mitotic Cell Cycle
Cell Differentiation
Regulation Of Apoptotic Process
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Cellular Response To Estrogen Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Kidney Development
Optic Vesicle Morphogenesis
Optic Cup Structural Organization
Regulation Of Transcription By RNA Polymerase II
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Retina Layer Formation
Negative Regulation Of Transcription By Competitive Promoter Binding
Trigeminal Nerve Development
Oculomotor Nerve Formation
Positive Regulation Of Bone Mineralization
Embryonic Forelimb Morphogenesis
Regulation Of Cell Population Proliferation
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Cranial Skeleton Morphogenesis
Anatomical Structure Development
Roof Of Mouth Development
Bone Morphogenesis
Eyelid Development In Camera-type Eye
Positive Regulation Of Tooth Mineralization
Cellular Response To Iron Ion
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
TFAP2 (AP-2) family regulates transcription of other transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
TFAP2 (AP-2) family regulates transcription of cell cycle factors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Diseases
Branchiooculofacial syndrome (BOFS)
GWAS
Refractive error (
32231278
)
Schizophrenia (
28991256
)
Serum immune biomarker levels (
32066700
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Breast cancer in BRCA2 mutation carriers (
23544012
)
Glucose homeostasis traits (
25524916
)
Iron status biomarkers (ferritin levels) (
28334935
)
Metabolite levels (
23823483
)
Ovarian cancer (
30557369
)
Refractive error (
32231278
)
Response to (pegylated) interferon in HBeAg-negative hepatitis B (
30715261
)
Zinc levels (
26025379
)
Interacting Genes
30 interacting genes:
ALX1
ATF1
ATF2
ATF3
ATF4
BLZF1
BTG2
CEBPA
CREB1
DDIT3
DMTF1
E2F3
EGR1
EGR2
ESR1
ESR2
ESRRG
ETS1
ETS2
FOS
FOSB
FOSL2
GATA1
GTF2B
GTF2H2
GTF3C5
HAND1
NR3C1
TFAP2A
UBE2Z
38 interacting genes:
APC
CASP1
CASP3
CASP6
CITED2
CITED4
CLTC
CSNK2A1
CSNK2B
CTNNB1
DEK
EP300
EPN1
EPN2
EPS15
GSTO2
HIP1
INCA1
KCTD15
LDLRAP1
MAGI1
MKRN3
MYC
NFKB1
NPM1
PPARG
PRKAA2
PRKD1
RB1
SRA1
SUMO4
SYT1
TP53
UBE2I
VEGFA
WWP1
WWP2
YBX1
Entrez ID
10011
7020
HPRD ID
18716
00128
Ensembl ID
ENSG00000213523
ENSG00000137203
Uniprot IDs
Q9HD15
P05549
PDB IDs
2MGX
4NBO
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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