UNG

Description		uracil DNA glycosylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)
Novel Interacting Genes		10 novel interacting genes: ATP2A2 CCDC33 CRY1 DAO FTH1 KERA P2RY6 PRDM4 RPS20 SLC17A7
Interacting Genes		5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2
Entrez ID		7374
HPRD ID		01881
Ensembl ID		ENSG00000076248
Uniprot IDs		E5KTA5 E5KTA6 P13051
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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