UNG and SEZ6L2

Data Source:
BioGRID (two hybrid)

		UNG	SEZ6L2
Description		uracil DNA glycosylase	seizure related 6 homolog like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anthropometric traits ( 19260139) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Body fat distribution (arm fat ratio) ( 30664634) Response to taxane treatment (placlitaxel) ( 23006423) Schizophrenia ( 28991256 25056061 29483656) Systemic lupus erythematosus ( 23273568)
Interacting Genes		5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2	7 interacting genes: ETV5 FOXA1 MTDH OASL TK1 TOX3 UNG
Entrez ID		7374	26470
HPRD ID		01881	06686
Ensembl ID		ENSG00000076248	ENSG00000174938
Uniprot IDs		E5KTA5 E5KTA6 P13051	A0A087WYL5 A0A0A8K8P7 B7Z5L4 Q6UXD5
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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