UNG and SLC17A7

Data Source:
BioGRID (affinity chromatography technology)

		UNG	SLC17A7
Description		uracil DNA glycosylase	solute carrier family 17 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Plasma Membrane Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Neuron Projection Intracellular Organelle Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Glutamate Transport Vesicle Membrane
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding	L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Sodium:inorganic Phosphate Symporter Activity Transmembrane Transporter Activity
	Biological Process	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Neural Retina Development Ion Transport Phosphate Ion Transport Anion Transport Brain Development Glutamate Secretion L-glutamate Transmembrane Transport Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Regulation Of Synapse Structure Or Activity Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Synaptic Vesicle Endocytosis
Pathways			Glutamate Neurotransmitter Release Cycle Organic anion transporters
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2	1 interacting genes: SH3GL2
Entrez ID		7374	57030
HPRD ID		01881	05551
Ensembl ID		ENSG00000076248	ENSG00000104888
Uniprot IDs		E5KTA5 E5KTA6 P13051	Q9P2U7
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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