UNG and PRDM4

Data Source:
BioGRID (proximity labelling technology)

		UNG	PRDM4
Description		uracil DNA glycosylase	PR/SET domain 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Cytoplasm Histone Methyltransferase Complex
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Transcription By RNA Polymerase II Regulation Of Gene Expression Histone H4-R3 Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			p75NTR negatively regulates cell cycle via SC1
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	Acne (severe) ( 24927181) Sleep duration ( 30846698)
Interacting Genes		5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2	7 interacting genes: CTNNBL1 EIF4E EMX1 MSRB3 NCS1 SERTAD1 SMAD3
Entrez ID		7374	11108
HPRD ID		01881	10425
Ensembl ID		ENSG00000076248	ENSG00000110851
Uniprot IDs		E5KTA5 E5KTA6 P13051	A0A024RBM7 B3KPI0 Q9UKN5
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7	2L9Z 3DB5
Enriched GO Terms of Interacting Partners?
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