BACE2

Description		beta-secretase 2
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)
Novel Interacting Genes		8 novel interacting genes: ABCA8 ACVR2A DIP2A ICOSLG LTC4S POFUT2 RAB27A UBASH3A
Interacting Genes		3 interacting genes: APP GGA1 GGA2
Entrez ID		25825
HPRD ID		05744
Ensembl ID		ENSG00000182240
Uniprot IDs		Q9Y5Z0
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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