BACE2 and DIP2A

Data Source:
BioGRID (affinity chromatography technology)

		BACE2	DIP2A
Description		beta-secretase 2	disco interacting protein 2 homolog A
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule	Nucleus Mitochondrion Cell Surface Membrane Dendritic Spine
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Acetate-CoA Ligase Activity Protein Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process	Acetyl-CoA Biosynthetic Process Negative Regulation Of Gene Expression Dendritic Spine Morphogenesis Positive Regulation Of Peptidyl-lysine Acetylation
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)	Anti-saccade response ( 29064472) Lymphocyte counts ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: APP GGA1 GGA2	19 interacting genes: ADAMTSL4 CCDC33 CEP44 DAB2 DLX2 FAM214B GPATCH2L IQUB JMJD6 MBIP PSME3 PTPN3 SORBS3 STAC3 TLE5 TMCC2 TRIM39 TRIP13 ZBTB43
Entrez ID		25825	23181
HPRD ID		05744	07611
Ensembl ID		ENSG00000182240	ENSG00000160305
Uniprot IDs		Q9Y5Z0	Q14689 Q96NX2
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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