BACE2 and ABCA8

Data Source:
BioGRID (affinity chromatography technology)

		BACE2	ABCA8
Description		beta-secretase 2	ATP binding cassette subfamily A member 8
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process	Sphingomyelin Biosynthetic Process Lipid Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Efflux Cholesterol Transport Cholesterol Efflux Xenobiotic Transport Transmembrane Transport
Pathways			ABC-family proteins mediated transport
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26582766) Coronary artery disease ( 29212778) group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol ( 25961943) Phosphorus levels ( 29403010) Soluble VCAM-1 levels ( 31217265) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		3 interacting genes: APP GGA1 GGA2
Entrez ID		25825	10351
HPRD ID		05744	09790
Ensembl ID		ENSG00000182240	ENSG00000141338
Uniprot IDs		Q9Y5Z0	A0A024R8L6 A0A0A0MSU4 O94911
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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