BACE2 and POFUT2

Data Source:
BioGRID (affinity chromatography technology)

		BACE2	POFUT2
Description		beta-secretase 2	protein O-fucosyltransferase 2
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule	Endoplasmic Reticulum Membrane Golgi Apparatus
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Peptide-O-fucosyltransferase Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process	Mesoderm Formation Fucose Metabolic Process Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Protein O-linked Fucosylation Regulation Of Secretion Positive Regulation Of Protein Folding
Pathways			O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)	Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		3 interacting genes: APP GGA1 GGA2
Entrez ID		25825	23275
HPRD ID		05744	09846
Ensembl ID		ENSG00000182240	ENSG00000186866
Uniprot IDs		Q9Y5Z0	Q9Y2G5 S6FW71
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1	4AP5 4AP6
Enriched GO Terms of Interacting Partners?
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