BACE2 and UBASH3A

Data Source:
BioGRID (genetic interference)

		BACE2	UBASH3A
Description		beta-secretase 2	ubiquitin associated and SH3 domain containing A
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Protein Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)	Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 21829393 25751624 19430480 30572963 18840781) Vitiligo ( 20410501 27723757)
Interacting Genes		3 interacting genes: APP GGA1 GGA2	89 interacting genes: ARRDC1 ARRDC3 BCAR3 C9orf24 CBLB CBS CCDC33 CD3E COPS9 DAZAP2 DDIT4L DISC1 DLGAP4 DNM2 DTX3 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 N4BP3 NSMF PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SNRNP48 SOS1 SPRY1 SPRY2 STX11 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B WAS WASL WBP11 ZBTB42 ZC2HC1C ZNF219 ZNF474 ZRANB1
Entrez ID		25825	53347
HPRD ID		05744	06904
Ensembl ID		ENSG00000182240	ENSG00000160185
Uniprot IDs		Q9Y5Z0	P57075
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1	2CRN 5WDI
Enriched GO Terms of Interacting Partners?
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