BRK1 and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		BRK1	PFDN1
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	prefoldin subunit 1
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Cytoplasm Prefoldin Complex
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		10 interacting genes: BRAP CYFIP2 HSBP1 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1	54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		55845	5201
HPRD ID		12818	05357
Ensembl ID		ENSG00000254999	ENSG00000113068
Uniprot IDs		Q8WUW1	O60925
PDB IDs		3P8C 4N78	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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