PFDN1 and DEFA1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		PFDN1	DEFA1
Description		prefoldin subunit 1	defensin alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Innate Immune Response In Mucosa Chemotaxis Immune Response T Cell Chemotaxis Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Protozoan Pore Formation In Membrane Of Other Organism During Symbiotic Interaction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Defensins Alpha-defensins Neutrophil degranulation
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	6 interacting genes: C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2
Entrez ID		5201	1667
HPRD ID		05357	00499
Ensembl ID		ENSG00000113068	ENSG00000206047
Uniprot IDs		O60925	P59665
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF
Enriched GO Terms of Interacting Partners?
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