PFDN1 and CHGA

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		PFDN1	CHGA
Description		prefoldin subunit 1	chromogranin A
Image
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Extracellular Region Extracellular Space Transport Vesicle Secretory Granule Chromaffin Granule Perinuclear Region Of Cytoplasm Neuronal Dense Core Vesicle
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Regulation Of The Force Of Heart Contraction Mast Cell Chemotaxis Organelle Organization Regulation Of Blood Pressure Killing Of Cells Of Other Organism Protein Localization To Secretory Granule Negative Regulation Of Catecholamine Secretion Defense Response To Bacterium Mast Cell Degranulation Innate Immune Response Mast Cell Activation Negative Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Cardiac Muscle Relaxation Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Dense Core Granule Biogenesis
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Antimicrobial peptides
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Blood protein levels ( 30072576) Body mass index ( 26426971)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	6 interacting genes: CDC37 NEK2 PFDN1 PLG SCG3 UBC
Entrez ID		5201	1113
HPRD ID		05357	07170
Ensembl ID		ENSG00000113068	ENSG00000100604
Uniprot IDs		O60925	G5E968 P10645 Q86T07
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	1LV4 6R2X
Enriched GO Terms of Interacting Partners?
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