PDS5B and PALB2

Number of citations of the paper that reports this interaction (PubMedID 27924011)
21

Data Source:
BioGRID (pull down)

		PDS5B	PALB2
Description		PDS5 cohesin associated factor B	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol	Nucleoplasm Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding	DNA Binding Protein Binding
	Biological Process	DNA Repair Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Bipolar disorder ( 17554300)
Interacting Genes		5 interacting genes: APP BRCA2 HASPIN PALB2 RAD51	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		23047	79728
HPRD ID		05624	07966
Ensembl ID		ENSG00000083642	ENSG00000083093
Uniprot IDs		Q9NTI5	H3BN63 Q86YC2
PDB IDs		5HDT	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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