PALB2 and IL24

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	IL24
Description		partner and localizer of BRCA2	interleukin 24
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Extracellular Region Extracellular Space
	Molecular Function	DNA Binding Protein Binding	Cytokine Activity Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Apoptotic Process Signal Transduction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Wound Healing Serine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Interleukin-20 family signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Inflammatory bowel disease ( 23128233)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	26 interacting genes: AKT1 APC ATM BAG4 CASP8 CCR5 CLU DCD ESR2 FBXW7 HMMR HRAS IL20RA KRAS LSP1 NOTCH2 PALB2 PARP1 PIK3CA PTEN RAD51 RARG RB1CC1 RIPK3 SMAD4 UBE3A
Entrez ID		79728	11009
HPRD ID		07966	04995
Ensembl ID		ENSG00000083093	ENSG00000162892
Uniprot IDs		H3BN63 Q86YC2	Q13007
PDB IDs		2W18 3EU7	6DF3 6GG1
Enriched GO Terms of Interacting Partners?
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