PALB2 and CST6

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	CST6
Description		partner and localizer of BRCA2	cystatin E/M
Image
GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Cornified Envelope Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Endopeptidase Activity
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Height ( 31562340) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A
Entrez ID		79728	1474
HPRD ID		07966	03535
Ensembl ID		ENSG00000083093	ENSG00000175315
Uniprot IDs		H3BN63 Q86YC2	Q15828
PDB IDs		2W18 3EU7	4N6L 4N6M 4N6N 4N6O 6FK0
Enriched GO Terms of Interacting Partners?
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