PALB2 and RAD51AP1

Number of citations of the paper that reports this interaction (PubMedID 20871616)
81

Data Source:
BioGRID (pull down)

		PALB2	RAD51AP1
Description		partner and localizer of BRCA2	RAD51 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Double-strand Break Repair Via Homologous Recombination DNA Repair Cellular Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	9 interacting genes: APP CACNA1C DMC1 LRRK2 MAP3K1 NEDD4 PALB2 RAD51 SIAH1
Entrez ID		79728	10635
HPRD ID		07966	04350
Ensembl ID		ENSG00000083093	ENSG00000111247
Uniprot IDs		H3BN63 Q86YC2	Q96B01
PDB IDs		2W18 3EU7
Enriched GO Terms of Interacting Partners?
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