PALB2 and NAT2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	NAT2
Description		partner and localizer of BRCA2	N-acetyltransferase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Cytosol
	Molecular Function	DNA Binding Protein Binding	Arylamine N-acetyltransferase Activity Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Xenobiotic Metabolic Process
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Acetylation
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bladder cancer ( 24163127 20972438) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Cholesterol, total ( 24097068 20686565) Coronary artery disease ( 29212778 33020668) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Insulin resistance/response ( 25798622) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver injury in anti-tuberculosis drug treatment ( 31109976) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Paclitaxel-induced neuropathy ( 23776197) Serum metabolite levels ( 33031748) Total cholesterol levels ( 28334899 33339817) Triglyceride levels ( 32203549 28334899 29403010 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 20686565) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414) Urinary metabolites (H-NMR features) ( 24586186) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	18 interacting genes: APC APP AURKA BAG4 CDKN2A CDKN2C CLU ERBB2 FZR1 HMMR IGF1R MBD4 NAA10 NBN PALB2 PPM1D STK11 WT1
Entrez ID		79728	10
HPRD ID		07966	02000
Ensembl ID		ENSG00000083093	ENSG00000156006
Uniprot IDs		H3BN63 Q86YC2	A4Z6T7 P11245
PDB IDs		2W18 3EU7	2PFR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?