DUSP9 and AATK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		DUSP9	AATK
Description		dual specificity phosphatase 9	apoptosis associated tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cellular_component Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade JNK Cascade Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade	Protein Phosphorylation Brain Development Biological_process Peptidyl-tyrosine Autophosphorylation
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Body mass index ( 28892062) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate ( 29403010) Hemoglobin A1c levels ( 29403010) Type 2 diabetes ( 23945395 22961080 20581827 30718926)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		7 interacting genes: AATK CDK4 GSK3B MAPK1 MAPK10 MAPK14 MAPK3	43 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP1CB PPP1CC PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2
Entrez ID		1852	9625
HPRD ID		02136	05591
Ensembl ID		ENSG00000130829	ENSG00000181409
Uniprot IDs		B2RAL9 Q6P9C2 Q99956	H7C175 Q6ZMQ8
PDB IDs		2HXP 3LJ8
Enriched GO Terms of Interacting Partners?
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