AATK and PPM1B

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		AATK	PPM1B
Description		apoptosis associated tyrosine kinase	protein phosphatase, Mg2+/Mn2+ dependent 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytosol Membrane
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation Brain Development Biological_process Peptidyl-tyrosine Autophosphorylation	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling
Pathways			ISG15 antiviral mechanism ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		43 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP1CB PPP1CC PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2	22 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAD2L2 MAP3K7 MSN MYL7 NCOA1 PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2
Entrez ID		9625	5495
HPRD ID		05591	04796
Ensembl ID		ENSG00000181409	ENSG00000138032
Uniprot IDs		H7C175 Q6ZMQ8	O75688
PDB IDs			2P8E
Enriched GO Terms of Interacting Partners?
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