PGRMC2 and ZDHHC21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PGRMC2	ZDHHC21
Description		progesterone receptor membrane component 2	zinc finger DHHC-type palmitoyltransferase 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endomembrane System Membrane Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Steroid Hormone Receptor Activity Steroid Binding Protein Binding Heme Transmembrane Transporter Activity Heme Binding	Protein Binding Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Heme Transport Steroid Hormone Mediated Signaling Pathway Adipose Tissue Development	Hair Follicle Development Regulation Of Vascular Associated Smooth Muscle Contraction Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Sebaceous Gland Development Regulation Of Nitric-oxide Synthase Activity Adrenergic Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	eNOS activation Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)	Age at first sexual intercourse ( 34211149) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Neuritic plaque ( 31497858) Schizophrenia ( 33169155) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		57 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LPAR3 MALL MFHAS1 MFSD5 ORMDL1 PEDS1-UBE2V1 PEX16 PGRMC1 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VAPA VEZT YIPF2 ZDHHC21 ZFPL1	12 interacting genes: AQP6 CHODL CREB3 ELOVL4 ERGIC3 FAM210B MTERF3 MUC1 PGRMC2 RNASEK TMEM167B TRIM59
Entrez ID		10424	340481
HPRD ID		09665	15716
Ensembl ID		ENSG00000164040	ENSG00000175893
Uniprot IDs		O15173	Q8IVQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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